Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug‐Drug Interactions? Preclinical and Clinical Studies With 13‐cis‐Retinoic Acid

All‐trans‐retinoic acid (at RA) downregulates cytochrome P450 (CYP)2D6 in several model systems. The aim of this study was to determine whether all active retinoids downregulate CYP2D6 and whether in vitro downregulation translates to in vivo drug–drug interactions (DDIs). The retinoids at RA, 13cis...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Stevison, Faith, Kosaka, Mika, Kenny, Jane R., Wong, Susan, Hogarth, Cathryn, Amory, John K., Isoherranen, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617839/
https://ncbi.nlm.nih.gov/pubmed/30681285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12616
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