Determinants of Cytochrome P450 2D6 mRNA Levels in Healthy Human Liver Tissue

Cytochrome P450 2D6 (CYP2D6) is a major drug‐metabolizing enzyme that exhibits large interindividual variability. Recent studies suggest that differential transcriptional regulation of CYP2D6 in part may be responsible for the variability. In this study, we characterized potential determinants of CY...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Ning, Miaoran, Duarte, Julio D., Stevison, Faith, Isoherranen, Nina, Rubin, Leah H., Jeong, Hyunyoung
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618095/
https://ncbi.nlm.nih.gov/pubmed/30821899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12632
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