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Surface-binding to Cardiolipin Nanodomains Triggers Cytochrome C Pro-apoptotic Peroxidase Activity via Localized Dynamics
The peroxidation of cardiolipins by reactive oxygen species (ROS), which is regulated and enhanced by cytochrome c (cyt c), is a critical signaling event in mitochondrial apoptosis. We probe the molecular underpinnings of this mitochondrial death signal through structural and functional studies of h...
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| Publicado no: | Structure |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6615723/ https://ncbi.nlm.nih.gov/pubmed/30879887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.02.007 |
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