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Enzymatic Transition States and Drug Design
Transition state theory teaches that chemically stable mimics of enzymatic transition states will bind tightly to their cognate enzymes. Kinetic isotope effects combined with computational quantum chemistry provides enzymatic transition state information with sufficient fidelity to design transition...
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| Udgivet i: | Chem Rev |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6615489/ https://ncbi.nlm.nih.gov/pubmed/30335982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrev.8b00369 |
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