De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair

Histone H2AX undergoes a phosphorylation switch from pTyr142 (H2AX-pY142) to pSer139 (γH2AX) in the DNA damage response (DDR); however, the functional role of H2AX-pY142 remains elusive. Here, we report a new layer of regulation involving transcription-coupled H2AX-pY142 in the DDR. We found that co...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Ji, Jae-Hoon, Min, Sunwoo, Chae, Sunyoung, Ha, Geun-Hyoung, Kim, Yonghyeon, Park, Yeon-Ji, Lee, Chang-Woo, Cho, Hyeseong
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614800/
https://ncbi.nlm.nih.gov/pubmed/31045206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz309
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