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De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair
Histone H2AX undergoes a phosphorylation switch from pTyr142 (H2AX-pY142) to pSer139 (γH2AX) in the DNA damage response (DDR); however, the functional role of H2AX-pY142 remains elusive. Here, we report a new layer of regulation involving transcription-coupled H2AX-pY142 in the DDR. We found that co...
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6614800/ https://ncbi.nlm.nih.gov/pubmed/31045206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz309 |
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