Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants

Regulation of homologous recombination (HR) represents the best-characterized DNA repair function of p53. The role of p53 phosphorylation in DNA repair is largely unknown. Here, we show that wild-type p53 repressed repair of DNA double-strand breaks (DSBs) by HR in a manner partially requiring the A...

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Detalhes bibliográficos
Main Authors: Restle, Anja, Färber, Martin, Baumann, Cindy, Böhringer, Michael, Scheidtmann, Karl Heinz, Müller-Tidow, Carsten, Wiesmüller, Lisa
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532731/
https://ncbi.nlm.nih.gov/pubmed/18697815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn503
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