H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions

Phosphorylated histone H2AX, termed ‘γH2AX’, mediates the chromatin response to DNA double strand breaks (DSBs) in mammalian cells. H2AX deficiency increases the numbers of unrepaired DSBs and translocations, which are partly associated with defects in non-homologous end joining (NHEJ) and contribut...

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Foilsithe in:Nucleic Acids Res
Main Authors: Feng, Yi-Li, Xiang, Ji-Feng, Liu, Si-Cheng, Guo, Tao, Yan, Guo-Fang, Feng, Ye, Kong, Na, Li, Hao- Dan, Huang, Yang, Lin, Hui, Cai, Xiu-Jun, Xie, An-Yong
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2017
Ábhair:
Genome Integrity, Repair and Replication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737864/
https://ncbi.nlm.nih.gov/pubmed/28977657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx715
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