H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions

Phosphorylated histone H2AX, termed ‘γH2AX’, mediates the chromatin response to DNA double strand breaks (DSBs) in mammalian cells. H2AX deficiency increases the numbers of unrepaired DSBs and translocations, which are partly associated with defects in non-homologous end joining (NHEJ) and contribut...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Feng, Yi-Li, Xiang, Ji-Feng, Liu, Si-Cheng, Guo, Tao, Yan, Guo-Fang, Feng, Ye, Kong, Na, Li, Hao- Dan, Huang, Yang, Lin, Hui, Cai, Xiu-Jun, Xie, An-Yong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Genome Integrity, Repair and Replication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737864/
https://ncbi.nlm.nih.gov/pubmed/28977657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx715
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