SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining

Aberrant end joining of DNA double strand breaks leads to chromosomal rearrangements and to insertion of nuclear or mitochondrial DNA into breakpoints, which is commonly observed in cancer cells and constitutes a major threat to genome integrity. However, the mechanisms that are causative for these...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Akimova, Ekaterina, Gassner, Franz Josef, Schubert, Maria, Rebhandl, Stefan, Arzt, Claudia, Rauscher, Stefanie, Tober, Vanessa, Zaborsky, Nadja, Greil, Richard, Geisberger, Roland
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2021
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969033/
https://ncbi.nlm.nih.gov/pubmed/33591315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab051
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