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SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining
Aberrant end joining of DNA double strand breaks leads to chromosomal rearrangements and to insertion of nuclear or mitochondrial DNA into breakpoints, which is commonly observed in cancer cells and constitutes a major threat to genome integrity. However, the mechanisms that are causative for these...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7969033/ https://ncbi.nlm.nih.gov/pubmed/33591315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab051 |
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