SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining

Aberrant end joining of DNA double strand breaks leads to chromosomal rearrangements and to insertion of nuclear or mitochondrial DNA into breakpoints, which is commonly observed in cancer cells and constitutes a major threat to genome integrity. However, the mechanisms that are causative for these...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Akimova, Ekaterina, Gassner, Franz Josef, Schubert, Maria, Rebhandl, Stefan, Arzt, Claudia, Rauscher, Stefanie, Tober, Vanessa, Zaborsky, Nadja, Greil, Richard, Geisberger, Roland
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969033/
https://ncbi.nlm.nih.gov/pubmed/33591315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab051
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