Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells

Defects in mitotic spindle orientation (MSO) disrupt the organization of stem cell niches impacting tissue morphogenesis and homeostasis. Mutations in centrosome genes reduce MSO fidelity, leading to tissue dysplasia and causing several diseases such as microcephaly, dwarfism, and cancer. Whether th...

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Publicat a:Dev Cell
Autors principals: Gambarotto, Davide, Pennetier, Carole, Ryniawec, John M., Buster, Daniel W., Gogendeau, Delphine, Goupil, Alix, Nano, Maddalena, Simon, Anthony, Blanc, Damien, Racine, Victor, Kimata, Yuu, Rogers, Gregory C., Basto, Renata
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614718/
https://ncbi.nlm.nih.gov/pubmed/31130353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.04.036
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