Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells

Defects in mitotic spindle orientation (MSO) disrupt the organization of stem cell niches impacting tissue morphogenesis and homeostasis. Mutations in centrosome genes reduce MSO fidelity, leading to tissue dysplasia and causing several diseases such as microcephaly, dwarfism, and cancer. Whether th...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Gambarotto, Davide, Pennetier, Carole, Ryniawec, John M., Buster, Daniel W., Gogendeau, Delphine, Goupil, Alix, Nano, Maddalena, Simon, Anthony, Blanc, Damien, Racine, Victor, Kimata, Yuu, Rogers, Gregory C., Basto, Renata
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614718/
https://ncbi.nlm.nih.gov/pubmed/31130353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.04.036
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