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Chromosomes function as a barrier to mitotic spindle bipolarity in polyploid cells
Ploidy variations such as genome doubling are frequent in human tumors and have been associated with genetic instability favoring tumor progression. How polyploid cells deal with increased centrosome numbers and DNA content remains unknown. Using Drosophila neuroblasts and human cancer cells to stud...
Shranjeno v:
| izdano v: | J Cell Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Rockefeller University Press
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7147111/ https://ncbi.nlm.nih.gov/pubmed/32328633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201908006 |
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