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Chromosomes function as a barrier to mitotic spindle bipolarity in polyploid cells
Ploidy variations such as genome doubling are frequent in human tumors and have been associated with genetic instability favoring tumor progression. How polyploid cells deal with increased centrosome numbers and DNA content remains unknown. Using Drosophila neuroblasts and human cancer cells to stud...
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| Publicat a: | J Cell Biol |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Rockefeller University Press
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7147111/ https://ncbi.nlm.nih.gov/pubmed/32328633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201908006 |
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