Chromosomes function as a barrier to mitotic spindle bipolarity in polyploid cells

Ploidy variations such as genome doubling are frequent in human tumors and have been associated with genetic instability favoring tumor progression. How polyploid cells deal with increased centrosome numbers and DNA content remains unknown. Using Drosophila neuroblasts and human cancer cells to stud...

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Bibliographic Details
Published in:J Cell Biol
Main Authors: Goupil, Alix, Nano, Maddalena, Letort, Gaëlle, Gemble, Simon, Edwards, Frances, Goundiam, Oumou, Gogendeau, Delphine, Pennetier, Carole, Basto, Renata
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147111/
https://ncbi.nlm.nih.gov/pubmed/32328633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201908006
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