Spindle Formation in the Mouse Embryo Requires Plk4 in the Absence of Centrioles

During the first five rounds of cell division in the mouse embryo, spindles assemble in the absence of centrioles. Spindle formation initiates around chromosomes, but the microtubule nucleating process remains unclear. Here we demonstrate that Plk4, a protein kinase known as a master regulator of ce...

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Bibliografiska uppgifter
Huvudupphovsmän: Coelho, Paula A., Bury, Leah, Sharif, Bedra, Riparbelli, Maria G., Fu, Jingyan, Callaini, Giuliano, Glover, David M., Zernicka-Goetz, Magdalena
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898710/
https://ncbi.nlm.nih.gov/pubmed/24268700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.09.029
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