Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes

Establishing the bipolar spindle in mammalian oocytes after their prolonged arrest is crucial for meiotic fidelity and subsequent development. In contrast to somatic cells, the first meiotic spindle assembles in the absence of centriole-containing centrosomes. Ran-GTP can promote microtubule nucleat...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Bury, Leah, Coelho, Paula A., Simeone, Angela, Ferries, Samantha, Eyers, Claire E., Eyers, Patrick A., Zernicka-Goetz, Magdalena, Glover, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2017
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674873/
https://ncbi.nlm.nih.gov/pubmed/28972102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201606077
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