A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease

Advances in the understanding of Alzheimer’s disease (AD) suggest that pathogenesis is not directly related to plaque burden, but rather to soluble toxic amyloid-beta oligomers (AßO). Therapeutic antibodies targeting Aß monomers and/or plaque have shown limited efficacy and dose-limiting adverse eve...

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Udgivet i:Sci Rep
Main Authors: Gibbs, Ebrima, Silverman, Judith M., Zhao, Beibei, Peng, Xubiao, Wang, Jing, Wellington, Cheryl L., Mackenzie, Ian R., Plotkin, Steven S., Kaplan, Johanne M., Cashman, Neil R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614461/
https://ncbi.nlm.nih.gov/pubmed/31285517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46306-5
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