A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease

Advances in the understanding of Alzheimer’s disease (AD) suggest that pathogenesis is not directly related to plaque burden, but rather to soluble toxic amyloid-beta oligomers (AßO). Therapeutic antibodies targeting Aß monomers and/or plaque have shown limited efficacy and dose-limiting adverse eve...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Gibbs, Ebrima, Silverman, Judith M., Zhao, Beibei, Peng, Xubiao, Wang, Jing, Wellington, Cheryl L., Mackenzie, Ian R., Plotkin, Steven S., Kaplan, Johanne M., Cashman, Neil R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614461/
https://ncbi.nlm.nih.gov/pubmed/31285517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46306-5
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados