Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells

Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research has focused on the hypermethylation phenotypes associated with (D)2-hydroxyglutarate (D2HG) accumulation, the metabolic consequences of these...

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Udgivet i:Cell Rep
Main Authors: Badur, Mehmet G., Muthusamy, Thangaselvam, Parker, Seth J., Ma, Shenghong, McBrayer, Samuel K., Cordes, Thekla, Magana, Jose H., Guan, Kun-Liang, Metallo, Christian M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613636/
https://ncbi.nlm.nih.gov/pubmed/30355481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.09.074
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