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Understanding the Monoclonal Antibody Disposition after Subcutaneous Administration using a Minimal Physiologically based Pharmacokinetic Model
PURPOSE: Monoclonal antibodies (mAbs) are commonly administered via subcutaneous (SC) route. However, bioavailability is often reduced after SC administration. In addition, the sequential transfer of mAbs through the SC tissue and lymphatic system is not completely understood. Therefore, major objec...
Shranjeno v:
| izdano v: | J Pharm Pharm Sci |
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| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6613546/ https://ncbi.nlm.nih.gov/pubmed/30011390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18433/jpps30028 |
| Oznake: |
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