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Predicting monoclonal antibody pharmacokinetics following subcutaneous administration via whole-body physiologically-based modeling
Use of the subcutaneous (SC) route for administering monoclonal antibodies (mAbs) to treat chronic conditions has been hindered because of an incomplete understanding of fundamental mechanisms controlling mAb absorption from the SC site, and due to the limited translatability of preclinical studies....
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| Publicado no: | J Pharmacokinet Pharmacodyn |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7529865/ https://ncbi.nlm.nih.gov/pubmed/32500362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-020-09691-3 |
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