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Proteolysis and oxidation of therapeutic proteins after intradermal or subcutaneous administration

The intradermal (ID) and subcutaneous (SC) routes are commonly used for therapeutic proteins (TPs) and vaccines; however, the bioavailability of TPs is typically less than small molecule drugs given via the same routes. Proteolytic enzymes in the dermal, SC and lymphatic tissues may be responsible f...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Pharm Sci
Main Authors: Varkhede, Ninad, Bommana, Rupesh, Schöneich, Christian, Forrest, M. Laird
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937400/
https://ncbi.nlm.nih.gov/pubmed/31408633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.08.005
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