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Proteolysis and oxidation of therapeutic proteins after intradermal or subcutaneous administration
The intradermal (ID) and subcutaneous (SC) routes are commonly used for therapeutic proteins (TPs) and vaccines; however, the bioavailability of TPs is typically less than small molecule drugs given via the same routes. Proteolytic enzymes in the dermal, SC and lymphatic tissues may be responsible f...
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| Publicado no: | J Pharm Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6937400/ https://ncbi.nlm.nih.gov/pubmed/31408633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.08.005 |
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