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Proteolysis and oxidation of therapeutic proteins after intradermal or subcutaneous administration
The intradermal (ID) and subcutaneous (SC) routes are commonly used for therapeutic proteins (TPs) and vaccines; however, the bioavailability of TPs is typically less than small molecule drugs given via the same routes. Proteolytic enzymes in the dermal, SC and lymphatic tissues may be responsible f...
Enregistré dans:
| Publié dans: | J Pharm Sci |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6937400/ https://ncbi.nlm.nih.gov/pubmed/31408633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.08.005 |
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