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Inference of clonal selection in cancer populations using single-cell sequencing data

SUMMARY: Intra-tumor heterogeneity is one of the major factors influencing cancer progression and treatment outcome. However, evolutionary dynamics of cancer clone populations remain poorly understood. Quantification of clonal selection and inference of fitness landscapes of tumors is a key step to...

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Détails bibliographiques
Publié dans:Bioinformatics
Auteurs principaux: Skums, Pavel, Tsyvina, Viachaslau, Zelikovsky, Alex
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612866/
https://ncbi.nlm.nih.gov/pubmed/31510696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz392
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