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Inference of clonal selection in cancer populations using single-cell sequencing data

SUMMARY: Intra-tumor heterogeneity is one of the major factors influencing cancer progression and treatment outcome. However, evolutionary dynamics of cancer clone populations remain poorly understood. Quantification of clonal selection and inference of fitness landscapes of tumors is a key step to...

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Detalhes bibliográficos
Publicado no:Bioinformatics
Main Authors: Skums, Pavel, Tsyvina, Viachaslau, Zelikovsky, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612866/
https://ncbi.nlm.nih.gov/pubmed/31510696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz392
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