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Inference of clonal selection in cancer populations using single-cell sequencing data

SUMMARY: Intra-tumor heterogeneity is one of the major factors influencing cancer progression and treatment outcome. However, evolutionary dynamics of cancer clone populations remain poorly understood. Quantification of clonal selection and inference of fitness landscapes of tumors is a key step to...

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Bibliografische gegevens
Gepubliceerd in:Bioinformatics
Hoofdauteurs: Skums, Pavel, Tsyvina, Viachaslau, Zelikovsky, Alex
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612866/
https://ncbi.nlm.nih.gov/pubmed/31510696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz392
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