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Inference of mutability landscapes of tumors from single cell sequencing data

One of the hallmarks of cancer is the extremely high mutability and genetic instability of tumor cells. Inherent heterogeneity of intra-tumor populations manifests itself in high variability of clone instability rates. Analogously to fitness landscapes, the instability rates of clonal populations fo...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Tsyvina, Viachaslau, Zelikovsky, Alex, Snir, Sagi, Skums, Pavel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728263/
https://ncbi.nlm.nih.gov/pubmed/33253159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008454
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