Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice

Cav1.2 is the pore‐forming subunit of L‐type voltage‐gated calcium channel (LTCC) that plays an important role in calcium overload and cell death in Alzheimer's disease. LTCC activity can be regulated by estrogen, a sex steroid hormone that is neuroprotective. Here, we investigated the potentia...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Lai, Yu‐Jie, Zhu, Bing‐Lin, Sun, Fei, Luo, Dong, Ma, Yuan‐Lin, Luo, Bio, Tang, Jing, Xiong, Ming‐Jian, Liu, Lu, Long, Yan, Hu, Xiao‐Tong, He, Ling, Deng, Xiao‐Juan, Zhang, John H., Yang, Jian, Yan, Zhen, Chen, Guo‐Jun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612642/
https://ncbi.nlm.nih.gov/pubmed/31012223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12961
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