Paricalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice

BACKGROUND: Recent studies have revealed that vitamin D deficiency may increase the risk of Alzheimer's disease, and vitamin D supplementation may be effective strategy to ameliorate the neurodegenerative process in Alzheimer's disease patients. Paricalcitol (PAL), a low-calcemic vitamin D...

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Bibliografski detalji
Izdano u:EBioMedicine
Glavni autori: Fan, Yong-Gang, Guo, Tian, Han, Xiao-Ran, Liu, Jun-Lin, Cai, Yu-Ting, Xue, Han, Huang, Xue-Shi, Li, Yan-Chun, Wang, Zhan-You, Guo, Chuang
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2019
Teme:
Research paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642335/
https://ncbi.nlm.nih.gov/pubmed/31303501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.07.014
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