Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice

Increased amyloid-β (Aβ) plaque deposition is thought to be the main cause of Alzheimer's disease (AD). β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is the key protein involved in Aβ peptide generation. Excessive expression of BACE1 might cause overproduction of neurotoxins in the...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neural Plast
Auteurs principaux: Tang, Yinshan, Shao, Shujun, Guo, Yu, Zhou, You, Cao, Jin, Xu, Anping, Wu, Jihong, Li, Zhigang, Xiang, Dulian
Format: Artigo
Langue:Inglês
Publié: Hindawi 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541940/
https://ncbi.nlm.nih.gov/pubmed/31223308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2823679
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