Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing

Voltage-gated sodium channels beta 2 (Navβ2, encoded by SCN2B) is a substrate of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and regulates cell surface expression of channels in neurons. Previous studies reported enhanced Navβ2 processing by BACE1 in Alzheimer’s disease (AD) model and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hu, Tao, Xiao, Zhangang, Mao, Rui, Chen, Bo, Lu, Min-Nan, Tong, Jun, Mei, Rong, Li, Shan-Shan, Xiao, Zhi-Cheng, Zhang, Lian-Feng, Xiyang, Yan-Bin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper: Gerotarget(Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725092/
https://ncbi.nlm.nih.gov/pubmed/29245901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21849
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