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Memantine Lowers Amyloid-beta Peptide Levels in Neuronal Cultures and in APP/PS1 Transgenic Mice

Memantine is a moderate-affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that stabilizes cognitive, functional, and behavioral decline in patients with moderate to severe Alzheimer’s disease (AD). In AD, the extracellular deposition of fibrillogenic amyloid-beta peptides (Aβ)...

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Bibliografische gegevens
Hoofdauteurs: Alley, George M., Bailey, Jason A, Chen, DeMao, Ray, Balmiki, Puli, Lakshman K., Tanila, Heikki, Banerjee, Pradeep K, Lahiri, Debomoy K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783840/
https://ncbi.nlm.nih.gov/pubmed/19642202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.22172
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