Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice

The aging brain with mitochondrial dysfunction and a reduced adenosine 5’-triphosphate (ATP) has been implicated in the onset and progression of β-Amyloid (Aβ)-induced neuronal toxicity in AD. To unravel the function of ATP and the underlying mechanisms on AD development, APP/PS1 double transgenic m...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Chen, Lizhi, Xu, Shicheng, Wu, Tong, Shao, Yijia, Luo, Li, Zhou, Lingqi, Ou, Shanshan, Tang, Hai, Huang, Wenhua, Guo, Kaihua, Xu, Jie
Format: Artigo
Language:Inglês
Published: Impact Journals 2019
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6914425/
https://ncbi.nlm.nih.gov/pubmed/31744937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102451
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