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Evolution of protein kinase substrate recognition at the active site

Protein kinases catalyse the phosphorylation of target proteins, controlling most cellular processes. The specificity of serine/threonine kinases is partly determined by interactions with a few residues near the phospho-acceptor residue, forming the so-called kinase-substrate motif. Kinases have bee...

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Détails bibliographiques
Publié dans:PLoS Biol
Auteurs principaux: Bradley, David, Beltrao, Pedro
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611643/
https://ncbi.nlm.nih.gov/pubmed/31233486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000341
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