Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer

Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well as TCRs that are concurrent safe and efficient. D...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Audehm, Stefan, Glaser, Manuel, Pecoraro, Matteo, Bräunlein, Eva, Mall, Sabine, Klar, Richard, Effenberger, Manuel, Albers, Julian, Bianchi, Henrique de Oliveira, Peper, Janet, Yusufi, Nahid, Busch, Dirk H., Stevanović, Stefan, Mann, Matthias, Antes, Iris, Krackhardt, Angela M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611213/
https://ncbi.nlm.nih.gov/pubmed/31316521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01485
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