Germline-Encoded TCR-MHC Contacts Promote TCR V Gene Bias in Umbilical Cord Blood T Cell Repertoire

T cells recognize antigens as peptides bound to major histocompatibility complex (MHC) proteins through T cell receptors (TCRs) on their surface. To recognize a wide range of pathogens, each individual possesses a substantial number of TCRs with an extremely high degree of variability. It remains co...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Gao, Kai, Chen, Lingyan, Zhang, Yuanwei, Zhao, Yi, Wan, Ziyun, Wu, Jinghua, Lin, Liya, Kuang, Yashu, Lu, Jinhua, Zhang, Xiuqing, Tian, Lei, Liu, Xiao, Qiu, Xiu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730489/
https://ncbi.nlm.nih.gov/pubmed/31543879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02064
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