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CRISPR knockout screen implicates three genes in lysosome function
Defective biosynthesis of the phospholipid PI(3,5)P(2) underlies neurological disorders characterized by cytoplasmic accumulation of large lysosome-derived vacuoles. To identify novel genetic causes of lysosomal vacuolization, we developed an assay for enlargement of the lysosome compartment that is...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6610096/ https://ncbi.nlm.nih.gov/pubmed/31270356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45939-w |
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