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Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene
The lipid phosphatase FIG4 is a subunit of the protein complex that regulates biosynthesis of the signaling lipid PI(3,5)P(2). Mutations of FIG4 result in juvenile lethality and spongiform neurodegeneration in the mouse, and are responsible for the human disorders Charcot–Marie–Tooth disease, Yunis–...
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| 發表在: | Hum Mol Genet |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4706117/ https://ncbi.nlm.nih.gov/pubmed/26604144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv480 |
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