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Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene

The lipid phosphatase FIG4 is a subunit of the protein complex that regulates biosynthesis of the signaling lipid PI(3,5)P(2). Mutations of FIG4 result in juvenile lethality and spongiform neurodegeneration in the mouse, and are responsible for the human disorders Charcot–Marie–Tooth disease, Yunis–...

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書目詳細資料
發表在:Hum Mol Genet
Main Authors: Lenk, Guy M., Frei, Christen M., Miller, Ashley C., Wallen, Rachel C., Mironova, Yevgeniya A., Giger, Roman J., Meisler, Miriam H.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706117/
https://ncbi.nlm.nih.gov/pubmed/26604144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv480
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