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Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration
FIG4 is a ubiquitously expressed phosphatase that, in complex with FAB1/PIKFYVE and VAC14, regulates the biosynthesis of the signaling lipid PI(3,5)P(2). Null mutation of Fig4 in the mouse results in spongiform degeneration of brain and peripheral ganglia, defective myelination and juvenile lethalit...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406753/ https://ncbi.nlm.nih.gov/pubmed/22581779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds179 |
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