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Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition
HMCES can covalently crosslink to abasic sites in single-stranded DNA at stalled replication forks to prevent genome instability. Here, we report crystal structures of the Human HMCES SRAP domain in complex with DNA-damage substrates, including HMCES crosslinked with an abasic site within a 3’ overh...
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| Vydáno v: | Nat Struct Mol Biol |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6609482/ https://ncbi.nlm.nih.gov/pubmed/31235913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0246-6 |
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