HMCES functions in the alternative end-joining pathway of the DNA DSB repair during class switch recombination in B cells.

HMCES (5hmC binding, ES-cell-specific-protein), originally identified as a protein capable of binding 5-hydroxymethylcytosine (5hmC), an epigenetic modification generated by TET proteins, was previously reported to covalently crosslink to DNA at abasic sites via a conserved cysteine. We show here th...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Shukla, Vipul, Halabelian, Levon, Balagere, Sanjana, Samaniego-Castruita, Daniela, Feldman, Douglas E., Arrowsmith, Cheryl H, Rao, Anjana, Aravind, L.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980713/
https://ncbi.nlm.nih.gov/pubmed/31806351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.031
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