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HMCES functions in the alternative end-joining pathway of the DNA DSB repair during class switch recombination in B cells.
HMCES (5hmC binding, ES-cell-specific-protein), originally identified as a protein capable of binding 5-hydroxymethylcytosine (5hmC), an epigenetic modification generated by TET proteins, was previously reported to covalently crosslink to DNA at abasic sites via a conserved cysteine. We show here th...
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| 發表在: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980713/ https://ncbi.nlm.nih.gov/pubmed/31806351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.031 |
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