Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition

HMCES can covalently crosslink to abasic sites in single-stranded DNA at stalled replication forks to prevent genome instability. Here, we report crystal structures of the Human HMCES SRAP domain in complex with DNA-damage substrates, including HMCES crosslinked with an abasic site within a 3’ overh...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Halabelian, Levon, Ravichandran, Mani, Li, Yanjun, Zeng, Hong, Rao, Anjana, Aravind, L., Arrowsmith, Cheryl H
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609482/
https://ncbi.nlm.nih.gov/pubmed/31235913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0246-6
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