HMCES maintains genome integrity by shielding abasic sites in single strand DNA

Abasic sites are one of the most common DNA lesions. All of the known abasic site repair mechanisms operate only when the damage is in double-stranded DNA. Here we report the discovery of HMCES as a sensor of abasic sites in single-stranded DNA. HMCES acts at replication forks, binds PCNA and single...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cell
Auteurs principaux: Mohni, Kareem N., Wessel, Sarah R., Zhao, Runxiang, Wojciechowski, Andrea C., Luzwick, Jessica W., Layden, Hillary, Eichman, Brandt F., Thompson, Petria S., Mehta, Kavi P. M., Cortez, David
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329640/
https://ncbi.nlm.nih.gov/pubmed/30554877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.055
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires