HMCES maintains genome integrity by shielding abasic sites in single strand DNA

Abasic sites are one of the most common DNA lesions. All of the known abasic site repair mechanisms operate only when the damage is in double-stranded DNA. Here we report the discovery of HMCES as a sensor of abasic sites in single-stranded DNA. HMCES acts at replication forks, binds PCNA and single...

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Udgivet i:Cell
Main Authors: Mohni, Kareem N., Wessel, Sarah R., Zhao, Runxiang, Wojciechowski, Andrea C., Luzwick, Jessica W., Layden, Hillary, Eichman, Brandt F., Thompson, Petria S., Mehta, Kavi P. M., Cortez, David
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329640/
https://ncbi.nlm.nih.gov/pubmed/30554877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.055
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