DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

The molecular mechanism controlling the zygotic genome activation (ZGA) in mammals remains poorly understood. The 2-cell (2C)-like cells spontaneously emerging from cultures of mouse embryonic stem cells (ESCs) share some key transcriptional and epigenetic programs with 2C-stage embryos. By studying...

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Publicado en:PLoS Biol
Autores principales: Yan, Yao-Long, Zhang, Chao, Hao, Jing, Wang, Xue-Lian, Ming, Jia, Mi, Li, Na, Jie, Hu, Xinli, Wang, Yangming
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608977/
https://ncbi.nlm.nih.gov/pubmed/31226106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000324
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