Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

DNA double-strand breaks (DSBs) are highly cytotoxic lesions that are generated by ionizing radiation (IR) and various DNA-damaging chemicals. Following DSB formation, cells activate the DNA-damage response (DDR) protein kinases ATM, ATR and DNA-PK. These then trigger histone H2AX phosphorylation an...

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Bibliografiset tiedot
Päätekijät: Galanty, Yaron, Belotserkovskaya, Rimma, Coates, Julia, Polo, Sophie, Miller, Kyle M., Jackson, Stephen P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904806/
https://ncbi.nlm.nih.gov/pubmed/20016603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08657
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