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Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
DNA double-strand breaks (DSBs) are highly cytotoxic lesions that are generated by ionizing radiation (IR) and various DNA-damaging chemicals. Following DSB formation, cells activate the DNA-damage response (DDR) protein kinases ATM, ATR and DNA-PK. These then trigger histone H2AX phosphorylation an...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2904806/ https://ncbi.nlm.nih.gov/pubmed/20016603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08657 |
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