Changes in mGlu5 Receptor-Dependent Synaptic Plasticity and Coupling to Homer Proteins in the Hippocampus of Ube3A Hemizygous Mice Modeling Angelman Syndrome

Angelman syndrome (AS) is caused by the loss of Ube3A, an ubiquitin ligase that commits specific proteins to proteasomal degradation. How this defect causes autism and other pathological phenotypes associated with AS is unknown. Long-term depression (LTD) of excitatory synaptic transmission mediated...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Pignatelli, Marco, Piccinin, Sonia, Molinaro, Gemma, Di Menna, Luisa, Riozzi, Barbara, Cannella, Milena, Motolese, Marta, Vetere, Gisella, Catania, Maria Vincenza, Battaglia, Giuseppe, Nicoletti, Ferdinando, Nisticò, Robert, Bruno, Valeria
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608124/
https://ncbi.nlm.nih.gov/pubmed/24672001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1846-13.2014
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