mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors

In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development. The cognate mGlu5 receptor is absent in mature PCs and shows low expression levels in the adult cerebell...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Notartomaso, Serena, Nakao, Harumi, Mascio, Giada, Scarselli, Pamela, Cannella, Milena, Zappulla, Cristina, Madonna, Michele, Motolese, Marta, Gradini, Roberto, Liberatore, Francesca, Zonta, Micaela, Carmignoto, Giorgio, Battaglia, Giuseppe, Bruno, Valeria, Watanabe, Masahiko, Aiba, Atsu, Nicoletti, Ferdinando
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127335/
https://ncbi.nlm.nih.gov/pubmed/30190524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31369-7
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