Alcohol‐induced miR‐155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease

Inflammation promotes the progression of alcoholic liver disease. Alcohol sensitizes KCs to gut‐derived endotoxin (LPS); however, signaling pathways that perpetuate inflammation in alcoholic liver disease are only partially understood. We found that chronic alcohol feeding in mice induced miR‐155, a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Leukoc Biol
Prif Awduron: Bala, Shashi, Csak, Timea, Kodys, Karen, Catalano, Donna, Ambade, Aditya, Furi, Istvan, Lowe, Patrick, Cho, Yeonhee, Iracheta‐Vellve, Arvin, Szabo, Gyongyi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2017
Pynciau:
Inflammation, Extracellular Mediators, & Effector Molecules
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608073/
https://ncbi.nlm.nih.gov/pubmed/28584078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0716-310R
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