Alcohol‐induced miR‐155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease

Inflammation promotes the progression of alcoholic liver disease. Alcohol sensitizes KCs to gut‐derived endotoxin (LPS); however, signaling pathways that perpetuate inflammation in alcoholic liver disease are only partially understood. We found that chronic alcohol feeding in mice induced miR‐155, a...

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Dades bibliogràfiques
Publicat a:J Leukoc Biol
Autors principals: Bala, Shashi, Csak, Timea, Kodys, Karen, Catalano, Donna, Ambade, Aditya, Furi, Istvan, Lowe, Patrick, Cho, Yeonhee, Iracheta‐Vellve, Arvin, Szabo, Gyongyi
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Inflammation, Extracellular Mediators, & Effector Molecules
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608073/
https://ncbi.nlm.nih.gov/pubmed/28584078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0716-310R
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