Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease

Activation of Kupffer cells (KCs) by gut-derived lipopolysaccharide (LPS) and Toll-Like Receptors 4 (TLR4)-LPS-mediated increase in TNFα production has a central role in the pathogenesis of alcoholic liver disease. Micro-RNA (miR)-125b, miR-146a, and miR-155 can regulate inflammatory responses to LP...

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Detalhes bibliográficos
Main Authors: Bala, Shashi, Marcos, Miguel, Kodys, Karen, Csak, Timea, Catalano, Donna, Mandrekar, Pranoti, Szabo, Gyongyi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020752/
https://ncbi.nlm.nih.gov/pubmed/21062749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.145870
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